Multi-layered omics datasets are generated from biospecimens donated by ROS and MAP participants, which include genetics, epigenetics, and next generation RNA-seq.
Other layers of omics data are generated from frozen dorsolateral prefrontal cortical tissue.
Please refer to each individual dataset below for details on tissue preparation and data processing pipelines.
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
SNP (Affymetrix) | Single Nucleotide Polymorphisms | 1709 |
Genotypes @ Synapse Imputed 1k @ Synapse |
SNP (Illumina) | Single Nucleotide Polymorphisms | 382 |
Genotypes @ Synapse Imputed 1k @ Synapse |
WES | Whole Exome Sequencing | 783 |
ADSP dbGaP |
WGS | Whole Genome Sequencing | 1164 | Synapse |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
H3K9Ac | Histone acetylation marks (ChIP-seq) | 714 | Synapse |
miRNA | MicroRNA expression | 702 | Synapse |
5 mc | DNA methylation 5-methylcytosine | 740 | Synapse |
5 hmC | DNA methylation 5-hydroxymethylcytosine | In Process | |
ATAC Seq | Chromatin Conformation | In Process |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
RNAseq | Next-generation RNA sequencing | 638 | Synapse |
RNA microarray | RNA microarray-measured gene expression | 492 | Synapse |
snRNAseq PFC | Single-nucleus RNA-seq of prefrontal cortex | 48 | Synapse |
RNAseq PFC microglia | RNA-seq of prefrontal cortex microglia | 10 | Synapse |
scRNAseq PFC microglia | Single-cell RNA-seq of prefrontal cortex | 13 | Synapse |
RNAseq monocyte | RNA-seq of peripheral blood mononuclear cell | 615 | Synapse |
snRNAseq | Single-nucleus RNA-seq of frozen brain | Synapse |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
Proteomics SRM | Selected reaction monitoring proteomics | 1225 | Documentation, Request, Synapse |
Proteomics TMT | Tandem mass tag proteomics | 160 | Documentation, Request, Synapse |
Proteomics ELISA | Presynaptic proteins and SNARE protein-protein interactions | 554 | Documentation, Request |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
Bile acid | Selected bile acid concentration in brain tissue | 111 | Documentation, Request, Synapse |
Brain metabolomics | Selected metabolites quantification in brain tissue | 111 | Documentation, Request, Synapse |
Serum metabolomics | Selected metabolites quantification in serum | 603 | Documentation, Request, Synapse |
Brain lipidomics | Targeted LC-MS measurements of 123 lipids in brain tissue | 99 | Documentation, Request |
Serum lipidomics | Targeted LC-MS measurements of 33 lipids in serum | 200 | Documentation, Request |