Variable Details

Available Studies

MAP

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

zsnare_6

Categories

Brain Proteins

Mean SNARE protein density
Mean SNARE protein density - Average of 6 regions (MAP only)

This variable is only available in MAP.

Mean Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor (SNARE) protein density is based on syntaxin-1, vesicle-associated membrane protein (VAMP), and synaptosomal-associated protein 25 (SNAP-25) densities, determined in the Honer Lab at the University of British Columbia (Vancouver BC, Canada). Immunodensities for each protein are quantified from frozen samples of gray matter in 6 cortical regions.

Antibody Target protein
SP6 Syntaxin-1
SP10 VAMP
SP12 SNAP-25

Brain regions:

  1. Hippocampus
  2. Middle frontal gyrus
  3. Inferior temporal gyrus
  4. Calcarine (visual) cortex
  5. Ventromedial caudate
  6. Posterior putamen

For each protein, values are expressed in log10 units, the mean is determined for each participant across the 6 brain regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. The mean SNARE protein density is the average of the syntaxin-1, VAMP, and SNAP-25 densities. Higher values indicate greater SNARE protein concentrations.


Publications