Available Studies
MAP
Categories
Brain Proteins
This variable is only available in MAP.
Mean complexin protein density is based on complexin-I and complexin-II protein densities, determined by immunoassay at the Honer Lab at the University of British Columbia (Vancouver BC, Canada). Monoclonal antibodies (see below) are used to quanitfy complexin-I and complexin-II immunodensities from frozen samples of gray matter in 6 cortical regions.
Antibody | Target protein |
---|---|
SP33 | Complexin-I (inhibitory) |
LP27 | Complexin-II (excitatory) |
Brain regions:
For each protein, values are expressed in log10 units, the mean is determined for each participant across the 6 brain regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. The mean complexin density is the average of the complexin-I and complexin-II densities. Higher values indicate greater complexin density.