Variable Details
Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
NIA-Reagan diagnosis of AD - OLD
NIA-Reagan Diagnosis of Alzheimer's disease - 4 levels (none to high likelihood)
This variable is based on NIA-Reagan diagnostic criteria. Please use adnc for the most up-to-date NIA-AA consensus pathologic diagnosis for AD.
The modified NIA-Reagan diagnosis of Alzheimer's disease is based on consensus recommendations for postmortem diagnosis of Alzheimer's disease. The criteria rely on both neurofibrillary tangles (Braak) and neuritic plaques (CERAD).
| Value | Likelihood of AD | DICHOTOMIZED (AD_REAGAN) |
|---|---|---|
| 1 | High | 1 |
| 2 | Intermediate | 1 |
| 3 | Low | 0 |
| 4 | No AD | 0 |
The criteria is modified because the neuropathological evaluation is done without knowledge of clinical information, including a diagnosis of dementia. The neuropathologist determines the level of AD pathology. Those with intermediate or high likelihood fulfill criteria for having a pathologic diagnosis of AD.