Variable Details

Available Studies
MAP
Scaled? 
Not Scaled
Variable Type 
Cross-Sectional
Variable Name 
synap_6_snap25
Categories
Brain Proteins

SNAP-25
Synaptosomal-associated protein 25 (SNAP-25) density - Average of 6 regions (MAP only)

This variable is only available in MAP.

Synaptosomal-associated protein 25 (SNAP-25) density is determined by immunoassay in the Honer Lab at the University of British Columbia (Vancouver BC, Canada). SP12 antibody is used to quantify SNAP-25 immunodensities from frozen samples of gray matter in 6 cortical regions:

  1. Hippocampus
  2. Middle frontal gyrus
  3. Inferior temporal gyrus
  4. Calcarine (visual) cortex
  5. Ventromeidal caudate
  6. Posterior putamen

Values are expressed in log10 units, the mean is determined for each participant across the 6 regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. Higher values indicate greater SNAP-25 protein concentrations.

Publications

Barakauskas VE, Beasley CL, Barr AM, Ypsilanti AR, Li HY, Thornton AE, Wong H, Rosokilja G, Mann JJ, Mancevski B, Jakovski Z, Davceva N, Ilievski B, Dwork AJ, Falkai P, Honer WG. A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 Apr; 35 (5):1226-38. PubMed PMID: 20072114; PubMedCentral PMCID: PMC3055413 Honer WG, Barr AM, Sawada K, Thornton AE, Morris MC, Leurgans SE, Schneider JA, Bennett DA. Cognitive reserve, presynaptic proteins and dementia in the elderly. Translational psychiatry. 2012; 2 (5):e114. PubMed PMID: 22832958; PubMedCentral PMCID: PMC3365257