Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
Neurofibrillary tangle burden is determined by microscopic examination of silver-stained slides from 5 regions: midfrontal cortex, midtemporal cortex, inferior parietal cortex, entorhinal cortex, and hippocampus. The count of each region is scaled by dividing by the corresponding standard deviation. The 5 scaled regional measures are then averaged to obtain a summary measure for neurofibrillary tangle burden.
Neurofibrillary tangle pathology counts by region:
Region | Variable |
---|---|
Entorhinal cortex | nft_ec |
Hippocampus (CA1) | nft_hip |
Midtemporal cortex | nft_mt |
Inferior parietal cortex | nft_ag |
Midfrontal cortex | nft_mf |
Burden across regions | nft |
Notes: Counts of tangles may be missing for regions (e.g., due to damage from infarct). If data are present for at least 2 of 5 regions, the summary measure for neurofibrillary tangle burden is computed.
Item level variables are available upon request.