Variable Details

Available Studies

MAP

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

synap_6_synaptophys

Categories

Brain Proteins

Synaptophysin
Synaptophysin protein density - Average of 6 regions (MAP only)

This variable is only available in MAP.

Synaptophysin protein density is determined by immunoassay in the Honer Lab at the University of British Columbia (Vancouver BC, Canada). EP10 antibody is used to quantify synaptophysin immunodensities from frozen samples of gray matter in 6 cortical regions:

  1. Hippocampus
  2. Middle frontal gyrus
  3. Inferior temporal gyrus
  4. Calcarine (visual) cortex
  5. Ventromedial caudate
  6. Posterior putamen

Values are expressed in log10 units, a mean is determined for each participant across the 6 brain regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. Higher values indicate greater synaptophysin protein concentrations.

Publications

Barakauskas VE, Beasley CL, Barr AM, Ypsilanti AR, Li HY, Thornton AE, Wong H, Rosokilja G, Mann JJ, Mancevski B, Jakovski Z, Davceva N, Ilievski B, Dwork AJ, Falkai P, Honer WG. A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 Apr; 35 (5):1226-38. PubMed PMID: 20072114; PubMedCentral PMCID: PMC3055413 Honer WG, Barr AM, Sawada K, Thornton AE, Morris MC, Leurgans SE, Schneider JA, Bennett DA. Cognitive reserve, presynaptic proteins and dementia in the elderly. Translational psychiatry. 2012; 2 (5):e114. PubMed PMID: 22832958; PubMedCentral PMCID: PMC3365257