Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

ci_num2_gct

Categories

Pathology

Presence of one or more gross chronic infarcts
Cerebral Infarctions - Binary - Gross-Chronic-Any Location

Presence of one or more gross chronic cerebral infarctions, determined by neuropathologic evaluations performed at Rush, blinded to clinical data, and reviewed by a board-certified neuropathologist.

Examination of infarcts documents age (acute/subacute/chronic), size, and location (side and region) of infarcts visible to the naked eye on fixed slabs. All grossly visualized and suspected macroscopic infarcts are dissected for histologic confirmation.

ValueCoding
1One or more gross chronic infarctions (regardless of location)
0No gross chronic Infarctions

Total gross infarcts (acute + subacute +chronic) are available upon request. Counts (as opposed to presence of 1 or more) are available upon request.

Publications

Schneider JA, Bienias JL, Wilson RS, Berry-Kravis E, Evans DA, Bennett DA. The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke. 2005 May; 36 (5):954-9. PubMed PMID: 15774818; PubMedCentral PMCID: Arvanitakis Z, Leurgans SE, Barnes LL, Bennett DA, Schneider JA. Microinfarct pathology, dementia, and cognitive systems. Stroke. 2011 Mar; 42 (3):722-7. PubMed PMID: 21212395; PubMedCentral PMCID: PMC3042494