Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

lb_7reg

Categories

Pathology

Lewy bodies (7 regions)
Presence of Lewy bodies in 7 regions (includes amygdala)

Presence of Lewy bodies (7 regions) is identified by immunohistochemistry with alpha-synuclein (Zymed, LB509; 1:50) using the avidin-biotin method with alkaline phosphatase as the color developer. The following 7 regions are examined:

  1. Substantia nigra
  2. Entorhinal cortex
  3. Anterior cingulate cortex
  4. Midfrontal cortex
  5. Superior or middle temporal cortex
  6. Inferior parietal cortex
  7. Amygdala
ValueCoding
0No Lewy bodies
1Presence of Lewy bodies

Note: The listed reference describes Lewy bodies - 6 regions and does not include the amygdala.

Publications

Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007 Dec 11; 69 (24):2197-204. PubMed PMID: 17568013; PubMedCentral PMCID: