Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

apoe_genotype

Categories

ApoE and TOMM40

ApoE genotype
Apolipoprotein E genotype

Apolipoprotein E (APOE) genotype

ValueCoding
22E2E2
23E2E3
24E2E4
33E3E3
34E3E4
44E4E4

DNA was extracted from PBMCs or brain. Genotyping was performed by Agencourt Bioscience Corporation utilizing high-throughput sequencing of codon 112 (position 3937) and codon 158 (position 4075) of exon 4 of the APOE gene on chromosome 19.

Data updated 6/23/2015

Participants were genotyped for APOE alleles by Polymorphic DNA Technologies.

All APOE data were generated by Polymorphic DNA Technologies as part of a collaboration with Allan Roses and Zinfandel. http://www.polymorphicdna.com/

Publications

Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. TOMM40'523 variant and cognitive decline in older persons with APOE ?3/3 genotype. Neurology. 2017 Feb 14; 88 (7):661-668. PubMed PMID: 28108637; PubMedCentral PMCID: PMC5317377