Multi-layered omics datasets are generated from biospecimens donated by ROS and MAP participants, which include genetics, epigenetics, and next generation RNA-seq.
Other layers of omics data are generated from frozen dorsolateral prefrontal cortical tissue.
Please refer to each individual dataset below for details on tissue preparation and data processing pipelines.
See also: Omics participant identifiers
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
SNP (Affymetrix) | Single Nucleotide Polymorphisms | 1709 |
Genotypes @ Synapse Imputed 1k @ Synapse |
SNP (Illumina) | Single Nucleotide Polymorphisms | 382 |
Genotypes @ Synapse Imputed 1k @ Synapse |
WES | Whole Exome Sequencing | 783 |
ADSP dbGaP |
WGS | Whole Genome Sequencing | 1425 |
Synapse Synapse |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
H3K9Ac | Histone acetylation marks (ChIP-seq) | 714 | Synapse |
miRNA | MicroRNA expression | 702 | Synapse |
5 mc | DNA methylation 5-methylcytosine | 740 | Synapse |
5 hmC | DNA methylation 5-hydroxymethylcytosine | 1060 | Request |
ATAC Seq | Chromatin Conformation | In Process |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
RNAseq | Next-generation RNA sequencing | 1417 | Request, Synapse |
RNA microarray | RNA microarray-measured gene expression | 492 | Synapse |
snRNAseq PFC | Single-nucleus RNA-seq of prefrontal cortex | 48 | Synapse |
RNAseq PFC microglia | RNA-seq of prefrontal cortex microglia | 10 | Synapse |
scRNAseq PFC microglia | Single-cell RNA-seq of prefrontal cortex | 13 | Synapse |
RNAseq monocyte | RNA-seq of peripheral blood mononuclear cell | 558 | Synapse |
snRNAseq | Single-nucleus RNA-seq of frozen brain | 639 | Request, Synapse |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
Proteomics SRM | Selected reaction monitoring proteomics | 1225 | Documentation, Request, Synapse |
Proteomics TMT | Tandem mass tag proteomics | 946 | Documentation, Request, Synapse |
Proteomics ELISA | Presynaptic proteins and SNARE protein-protein interactions | 554 | Documentation, Request |
Proteomics Somalogic | Plasma proteomics | 671 | Request |
Type | Description | Sample Size | More Info / Request Data |
---|---|---|---|
Bile acid | Selected bile acid concentration in brain tissue | 111 | Documentation, Request, Synapse |
Brain metabolomics | Selected metabolites quantification in brain tissue | 111 | Documentation, Request, Synapse |
Serum metabolomics | Selected metabolites quantification in serum | 603 | Documentation, Request, Synapse |
Brain lipidomics | Targeted LC-MS measurements of 123 lipids in brain tissue | 99 | Documentation, Request |
Serum lipidomics | Targeted LC-MS measurements of 33 lipids in serum | 200 | Documentation, Request |
Brain metabolomics Metabolon | Metabolites quantification in brain tissue (Metabolon) | 514 | Synapse |
Brain lipidomics | LC-MS measurements of lipids in brain tissue | 384 | Synapse |