Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

c_score

Categories

Pathology

C score
Neuritic plaque score (4 levels), derived from CERAD

Neuritic plaque (CERAD) score is based on a semiquantitative measure of neuritic plaques (see CERAD score). A neuropathologic diagnosis was made based on semiquantitative estimates of neuritic plaque density as recommended by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), modified to be implemented without adjustment for age and clinical diagnosis. Diagnosis includes algorithm and neuropathologist’s opinion, blinded to age and all clinical data.

ValueCodingceradsc value
0No neuritic plaques4 = No AD
1Sparse neuritic plaques3 = Possible AD
2Moderate neuritic plaques2 = Probable AD
3Frequent neuritic plaques1 = Definite AD

Publications