Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

braaksc

Categories

Pathology

Braak stage
Semiquantitative measure of neurofibrillary tangles

Braak Stage is a semiquantitative measure of severity of neurofibrillary tangle (NFT) pathology. Bielschowsky silver stain was used to visualize NFTs in the frontal, temporal, parietal, entorhinal cortex, and the hippocampus. Braak stages were based upon the distribution and severity of NFT pathology:

Braak stages I and II indicate NFTs confined mainly to the entorhinal region of the brain Braak stages III and IV indicate involvement of limbic regions such as the hippocampus Braak stages V and VI indicate moderate to severe neocortical involvement.

Diagnosis includes algorithm and neuropathologist's opinion.

ValueCoding
00
1I
2II
3III
4IV
5V
6VI

Publications