Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

tdp_st4

Categories

Pathology

TDP-43 stage
TDP-43 pathology - 4 stages (8 regions)

As of 03/2019, this variable replaces tdp_stage4.

TDP-43 immunohistochemistry was performed on 8 brain regions using phosphorylated monoclonal TAR5P-1D3 (pS409/410; 1:100, Ascenion, Munich, Germany) TDP-43 antibody. Since 2015, this antibody has been obtained from MilliporeSigma, Burlington, MA.

  1. Amygdala
  2. Entorhinal cortex
  3. Hippocampus CA1
  4. Hippocampus dentate gyrus
  5. Anterior temporal pole cortex
  6. Midtemporal cortex
  7. Orbital frontal cortex
  8. Midfrontal cortex

Presence of TDP-43 cytoplasmic inclusions in neurons and glia are determined for each region (yes vs. no), and four stages of TDP-43 distribution are recognized:

ValueCodingRegions (see above)
0NoneNone
1Amygdala#1
2Amygdala + Limbic#1-4
3Amygdala + Limbic + Neocortical#1-8

If creating a dichotomized version of this variable, RADC recommends the following:

ValueCoding
0No TDP-43 pathology or TDP-43 pathology in amygdala only (Stages 0 and 1)
1TDP-43 pathology extending beyond amygdala (Stages 2 and 3)

Note: The listed reference describes a 2-stage and 6-stage version of TDP-43.


Publications