Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

adnc

Categories

Pathology

AD neuropathologic change (4 levels)
AD neuropathologic change based on NIA-AA criteria - 4 levels

AD neuropathologic change (4 levels)

The updated National Institute on Aging-Alzheimer's Association criteria is based on consensus recommendations for postmortem diagnosis of Alzheimer's disease. The criteria rely on a combination of neurofibrillary tangles (Braak), neuritic plaque score (CERAD), and Amyloid beta plaque score (Thal). The neuropathologist determines the level of AD pathology.

ValueLikelihood of ADDICHOTOMIZED (AD_adnc)
0No AD0
1Low0
2Intermediate1
3High1

See AD neuropathologic change - 2 levels for the dichotomized version of this variable.

This variable replaces "niareagansc", which was based on NIA-Reagan diagnostic criteria.


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