Variable Details
Available Studies
MAP
Categories
Brain Proteins
Mean SNARE protein-protein interactions
Mean SNARE protein-protein interactions - Average of 6 regions (MAP only)
This variable is only available in MAP.
Mean Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor (SNARE) protein-protein interactions captures the functional capacity of the presynaptic terminals to release neurotransmitters upon stimuli. Protein-protein interactions between different antigens are quantified from frozen samples of gray matter in 6 cortical regions. The measure is determined in the Honer Lab at the University of British Columbia (Vancouver BC, Canada).
| Antibodies | Synaptic protein interaction |
|---|---|
| SP7 + SP10 | Syntaxin-1 - VAMP interaction |
| SP7 + SP12 | Syntaxin-1 - SNAP-25 interaction |
| SP12 + SP7 | SNAP-25 - Syntaxin-1 interaction |
| SP12 + SP10 | SNAP-25 - VAMP interaction |
Brain regions:
- Hippocampus
- Middle frontal gyrus
- Inferior temporal gyrus
- Calcarine (visual) cortex
- Ventromedial caudate
- Posterior putamen
For each of the 4 protein-protein interactions, values are expressed in log10 units, the mean is determined for each participant across the 6 brain regions, and a standardized score is calculated across all participants. Since reported values are inversely proportional to protein-protein interaction levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. The mean SNARE protein-protein interactions is the average of the 4 protein-protein interactions. Higher values indicate more SNARE protein-protein interactions.
Note: This variable is not recommended to account for synaptic pathology.
Key: SNAP-25 = Synaptosomal-associated protein 25 VAMP = Vesicle-associated membrane protein