Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core

Scaled? 

Scaled

Variable Type 

Cross-Sectional

Variable Name 

cognwo_path_slope

Categories

Cognition

Random slope of working memory (demographics + pathology)
Estimated slope for working memory controlled for demographics and pathology

The random slope of working memory (demographics + pathology) is the estimated person-specific rate of change in the working memory domain variable over time, controlled for the following demographics and pathology. It comes from a linear mixed effects model with working memory as the outcome.

Demographics:

  1. Age at baseline
  2. Sex
  3. Years of education

Pathology:

  1. Global AD pathology burden
  2. Amyloid beta
  3. PHF tau tangles
  4. Gross chronic cerebral infarctions
  5. Chronic microinfarctions
  6. Lewy body disease
  7. TDP-43
  8. Hippocampal sclerosis
  9. Cerebral amyloid angiopathy
  10. Cerebral atherosclerosis
  11. Arteriolosclerosis

Notes: Time in this model refers to years from date of death.

The listed reference describes the model adjusting for demographics.


Publications