Variable Details

Available Studies

MAP

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

zcomplexin_6

Categories

Brain Proteins

Mean complexin density
Mean complexin density - Average of 6 regions (MAP only)

This variable is only available in MAP.

Mean complexin protein density is based on complexin-I and complexin-II protein densities, determined by immunoassay at the Honer Lab at the University of British Columbia (Vancouver BC, Canada). Monoclonal antibodies (see below) are used to quanitfy complexin-I and complexin-II immunodensities from frozen samples of gray matter in 6 cortical regions.

Antibody Target protein
SP33 Complexin-I (inhibitory)
LP27 Complexin-II (excitatory)

Brain regions:

  1. Hippocampus
  2. Middle frontal gyrus
  3. Inferior temporal gyrus
  4. Calcarine (visual) cortex
  5. Ventromedial caudate
  6. Posterior putamen

For each protein, values are expressed in log10 units, the mean is determined for each participant across the 6 brain regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. The mean complexin density is the average of the complexin-I and complexin-II densities. Higher values indicate greater complexin density.


Publications