Variable Details
Mean SNARE protein density
Mean SNARE protein density - Average of 6 regions (MAP only)
This variable is only available in MAP.
Mean Soluble N-ethylmaleimide-sensitive factor Attachment protein Receptor (SNARE) protein density is based on syntaxin-1, vesicle-associated membrane protein (VAMP), and synaptosomal-associated protein 25 (SNAP-25) densities, determined in the Honer Lab at the University of British Columbia (Vancouver BC, Canada). Immunodensities for each protein are quantified from frozen samples of gray matter in 6 cortical regions.
| Antibody | Target protein |
|---|---|
| SP6 | Syntaxin-1 |
| SP10 | VAMP |
| SP12 | SNAP-25 |
Brain regions:
- Hippocampus
- Middle frontal gyrus
- Inferior temporal gyrus
- Calcarine (visual) cortex
- Ventromedial caudate
- Posterior putamen
For each protein, values are expressed in log10 units, the mean is determined for each participant across the 6 brain regions, and a z-score is calculated across all participants. Since reported values are inversely proportional to protein levels, scores are multiplied by negative 1 to make results directly related to the amount of target antigen. The mean SNARE protein density is the average of the syntaxin-1, VAMP, and SNAP-25 densities. Higher values indicate greater SNARE protein concentrations.