Variable Details

Available Studies
ROS, MAP, MARS, Clinical Core
Scaled? 
Scaled
Variable Type 
Cross-Sectional
Variable Name 
cognep_path_slope
Categories
Cognition

Random slope of episodic memory (demographics + pathology)
Estimated slope for episodic memory controlled for demographics and pathology

The random slope of episodic memory (demographics + pathology) is the estimated person-specific rate of change in the episodic memory domain variable over time, controlled for the following demographics and pathology. It comes from a linear mixed effects model with episodic memory as the outcome.

Demographics:

  1. Age at death
  2. Sex
  3. Years of education

Pathology:

  1. Global AD pathology burden
  2. Amyloid beta
  3. PHF tau tangles
  4. Gross chronic cerebral infarctions
  5. Chronic microinfarctions
  6. Lewy body disease
  7. TDP-43
  8. Hippocampal sclerosis
  9. Cerebral amyloid angiopathy
  10. Cerebral atherosclerosis
  11. Arteriolosclerosis

Notes: Time in this model refers to years from date of death.

The listed reference describes the model adjusting for demographics.

Publications

De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, Yu L, Leurgans SE, Tran D, Aubin C, Anderson CD, Biffi A, Corneveaux JJ, Huentelman MJ, Rosand J, Daly MJ, Myers AJ, Reiman EM, Bennett DA, Evans DA. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiology of aging. 2011 Nov 3; 33 (5):1017.e1-1017.e15. PubMed PMID: 22054870; PubMedCentral PMCID: PMC3307898