Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
As of 03/2019, this variable replaces tdp_stage4.
TDP-43 immunohistochemistry was performed on 8 brain regions using phosphorylated monoclonal TAR5P-1D3 (pS409/410; 1:100, Ascenion, Munich, Germany) TDP-43 antibody. Since 2015, this antibody has been obtained from MilliporeSigma, Burlington, MA.
Amygdala
Entorhinal cortex
Hippocampus CA1
Hippocampus dentate gyrus
Anterior temporal pole cortex
Midtemporal cortex
Orbital frontal cortex
Midfrontal cortex
Presence of TDP-43 cytoplasmic inclusions in neurons and glia are determined for each region (yes vs. no), and four stages of TDP-43 distribution are recognized:
Value | Coding | Regions (see above) |
---|---|---|
0 | None | None |
1 | Amygdala | #1 |
2 | Amygdala + Limbic | #1-4 |
3 | Amygdala + Limbic + Neocortical | #1-8 |
If creating a dichotomized version of this variable, RADC recommends the following:
Value | Coding |
---|---|
0 | No TDP-43 pathology or TDP-43 pathology in amygdala only (Stages 0 and 1) |
1 | TDP-43 pathology extending beyond amygdala (Stages 2 and 3) |
Note: The listed reference describes a 2-stage and 6-stage version of TDP-43.