Neuritic plaque (CERAD) score is based on a semiquantitative measure of neuritic plaques (see CERAD score). A neuropathologic diagnosis was made based on semiquantitative estimates of neuritic plaque density as recommended by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), modified to be implemented without adjustment for age and clinical diagnosis. Diagnosis includes algorithm and neuropathologist’s opinion, blinded to age and all clinical data.