Variable Details
Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
CERAD score
Semiquantitative measure of neuritic plaques
CERAD score is a semiquantitative measure of neuritic plaques. A neuropathologic diagnosis was made of no AD, possible AD, probable AD, or definite AD based on semiquantitative estimates of neuritic plaque density as recommended by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), modified to be implemented without adjustment for age and clinical diagnosis. A CERAD neuropathologic diagnosis of AD required moderate (probable AD) or frequent neuritic plaques (definite AD) in one or more neocortical regions.
Diagnosis includes algorithm and neuropathologist's opinion, blinded to age and all clinical data.
| Value | Coding | If using a binary variable, recommendation is |
|---|---|---|
| 1 | Definite | yes |
| 2 | Probable | yes |
| 3 | Possible | no |
| 4 | No AD | no |
Publications
Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006 Jun 27; 66 (12):1837-44. PubMed PMID: 16801647; PubMedCentral PMCID:
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991 Apr; 41 (4):479-86. PubMed PMID: 2011243; PubMedCentral PMCID: