Variable Details
Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
Presence of one or more gross chronic infarcts
Cerebral Infarctions - Binary - Gross-Chronic-Any Location
Presence of one or more gross chronic cerebral infarctions, determined by neuropathologic evaluations performed at Rush, blinded to clinical data, and reviewed by a board-certified neuropathologist.
Examination of infarcts documents age (acute/subacute/chronic), size, and location (side and region) of infarcts visible to the naked eye on fixed slabs. All grossly visualized and suspected macroscopic infarcts are dissected for histologic confirmation.
| Value | Coding |
|---|---|
| 1 | One or more gross chronic infarctions (regardless of location) |
| 0 | No gross chronic Infarctions |
Total gross infarcts (acute + subacute +chronic) are available upon request. Counts (as opposed to presence of 1 or more) are available upon request.
Publications
Schneider JA, Bienias JL, Wilson RS, Berry-Kravis E, Evans DA, Bennett DA. The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke. 2005 May; 36 (5):954-9. PubMed PMID: 15774818; PubMedCentral PMCID:
Arvanitakis Z, Leurgans SE, Barnes LL, Bennett DA, Schneider JA. Microinfarct pathology, dementia, and cognitive systems. Stroke. 2011 Mar; 42 (3):722-7. PubMed PMID: 21212395; PubMedCentral PMCID: PMC3042494