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Measures of metabolism
This data set is available for a subset of ROS participants.
Basal and insulin-stimulated levels of signaling and regulating kinases upstream and downstream in the IR→IRS-1/2→PI3K→Akt pathway are quantified using ex vivo stimulation, Western blotting, and quantitative immunohistochemistry.
Insulin and IGF-1 responsiveness are tested in the hippocampal formation.
Reference: Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE: Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 2012, 122(4):1316-38.