Variable Details

Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Scaled? 
Not Scaled
Variable Type 
Cross-Sectional
Variable Name 
adnc
Categories
Pathology

AD neuropathologic change (4 levels)
AD neuropathologic change based on NIA-AA criteria - 4 levels

AD neuropathologic change (4 levels)

The updated National Institute on Aging-Alzheimer's Association criteria is based on consensus recommendations for postmortem diagnosis of Alzheimer's disease. The criteria rely on a combination of neurofibrillary tangles (Braak), neuritic plaque score (CERAD), and Amyloid beta plaque score (Thal). The neuropathologist determines the level of AD pathology.

ValueLikelihood of ADDICHOTOMIZED (AD_adnc)
0No AD0
1Low0
2Intermediate1
3High1

See AD neuropathologic change - 2 levels for the dichotomized version of this variable.

This variable replaces "niareagansc", which was based on NIA-Reagan diagnostic criteria.

Publications

Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2012 Jan; 8 (1):1-13. PubMed PMID: 22265587; PubMedCentral PMCID: PMC3266529