Variable Details

Available Studies

ROS, MAP, MARS, Clinical Core, LATC

Scaled? 

Not Scaled

Variable Type 

Cross-Sectional

Variable Name 

niareagansc

Categories

Pathology

NIA-Reagan diagnosis of AD - OLD
NIA-Reagan Diagnosis of Alzheimer's disease - 4 levels (none to high likelihood)

This variable is based on NIA-Reagan diagnostic criteria. Please use adnc for the most up-to-date NIA-AA consensus pathologic diagnosis for AD.

The modified NIA-Reagan diagnosis of Alzheimer's disease is based on consensus recommendations for postmortem diagnosis of Alzheimer's disease. The criteria rely on both neurofibrillary tangles (Braak) and neuritic plaques (CERAD).

ValueLikelihood of ADDICHOTOMIZED (AD_REAGAN)
1High1
2Intermediate1
3Low0
4No AD0

The criteria is modified because the neuropathological evaluation is done without knowledge of clinical information, including a diagnosis of dementia. The neuropathologist determines the level of AD pathology. Those with intermediate or high likelihood fulfill criteria for having a pathologic diagnosis of AD.


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