Variable Details
Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
Global AD pathology burden
Global burden of AD pathology based on 5 regions
Global AD pathology burden is a quantitative summary of AD pathology derived from counts of three AD pathologies: neuritic plaques (n), diffuse plaques (d), and neurofibrillary tangles (nft), as determined by microscopic examination of silver-stained slides from 5 regions: midfrontal cortex (midfrontal), midtemporal cortex (midtemp), inferior parietal cortex (infparietal), entorhinal cortex (ento), and hippocampus (ca1hip). The resulting 15 regional counts are shown in the Table. Each regional count is scaled by dividing by the corresponding standard deviation. The 5 scaled regional measures for each type of pathology are then averaged to obtain summary measures (plaq_d, plaq_n, and nft) . The 3 summary measures are then averaged to obtain the measure of global AD pathology.
Table of AD pathology counts by region
| Region | Diffuse Plaques | Neuritic Plaques | Neurofibrillary tangles |
|---|---|---|---|
| Entorhinal cortex | plaq_d_ec | plaq_n_ec | nft_ec |
| Hippocampus (CA1) | plaq_d_hip | plaq_n_hip | nft_hip |
| Midtemporal cortex | plaq_d_mt | plaq_n_mt | nft_mt |
| Inferior parietal cortex | plaq_d_ag | plaq_n_ag | nft_ag |
| Midfrontal cortex | plaq_d_mf | plaq_n_mf | nft_mf |
| Burden across region | plaq_d | plaq_n | nft |
gpath = mean of (plaq_d, plaq_n, nft)
Notes on missing data and computation of measures: Counts may be missing for regions (e.g., due to damage from infarct). If data are present for at least 2 of 5 regions, the burden summary for a specific pathology is computed. The global AD pathology burden is only computed if all 3 of the pathology-specific summaries are valid (and nonmissing).
Item level variables are available upon request.