Variable Details
Available Studies
ROS, MAP, MARS, Clinical Core, LATC
Categories
Pathology
NIA-Reagan diagnosis of AD - OLD
NIA-Reagan Diagnosis of Alzheimer's disease - 4 levels (none to high likelihood)
This variable is based on NIA-Reagan diagnostic criteria. Please use adnc for the most up-to-date NIA-AA consensus pathologic diagnosis for AD.
The modified NIA-Reagan diagnosis of Alzheimer's disease is based on consensus recommendations for postmortem diagnosis of Alzheimer's disease. The criteria rely on both neurofibrillary tangles (Braak) and neuritic plaques (CERAD).
| Value | Likelihood of AD | DICHOTOMIZED (AD_REAGAN) |
|---|---|---|
| 1 | High | 1 |
| 2 | Intermediate | 1 |
| 3 | Low | 0 |
| 4 | No AD | 0 |
The criteria is modified because the neuropathological evaluation is done without knowledge of clinical information, including a diagnosis of dementia. The neuropathologist determines the level of AD pathology. Those with intermediate or high likelihood fulfill criteria for having a pathologic diagnosis of AD.
Publications
Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006 Jun 27; 66 (12):1837-44. PubMed PMID: 16801647; PubMedCentral PMCID:
. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiology of aging. 1997 Jul-Aug; 18 (4 Suppl):S1-2. PubMed PMID: 9330978; PubMedCentral PMCID: